Skip to main content

A vitamin could help treat Duchenne muscular dystrophy

A vitamin could help treat Duchenne muscular dystrophy

Date:
October 19, 2016
Source:
Ecole Polytechnique Fédérale de Lausanne
Summary:
Researchers are working on a new strategy to combat one of the most severe forms of muscular dystrophy. Rather than acting on the defective gene, they are using large doses of a vitamin.
Duchenne is the most common and severe form of muscular dystrophy. Because of this genetic disease, one out of every 3,500 children spends their 12th birthday in a wheelchair. This disorder progressively leads to general paralysis, and most patients die of respiratory failure. The disease is caused by a genetic mutation that prevents a protein required to keep muscle cells intact from being produced. While most research focuses on repairing the defective gene, researchers at EPFL have come up with a different strategy. As part of their work on nutrition and aging, they discovered that large doses of a vitamin called nicotinamide riboside were remarkably effective in countering the progress of the disease in animals. Their work has been published in Science Translational Medicine.

Journal Reference:

  1. D. Ryu, H. Zhang, E. R. Ropelle, V. Sorrentino, D. A. G. Mazala, L. Mouchiroud, P. L. Marshall, M. D. Campbell, A. S. Ali, G. M. Knowels, S. Bellemin, S. R. Iyer, X. Wang, K. Gariani, A. A. Sauve, C. Canto, K. E. Conley, L. Walter, R. M. Lovering, E. R. Chin, B. J. Jasmin, D. J. Marcinek, K. J. Menzies, J. Auwerx. NAD repletion improves muscle function in muscular dystrophy and counters global PARylation. Science Translational Medicine, 2016; 8 (361): 361ra139 DOI: 10.1126/scitranslmed.aaf5504

Labels

Labels:

Comments

Post a Comment

Popular posts from this blog

Essential Minerals

Minerals: Functions and Sources The body needs many minerals; these are called essential minerals . Essential minerals are sometimes divided up into major minerals (macrominerals) and trace minerals (microminerals).  A balanced diet usually provides all of the essential minerals. The two tables below list minerals, what they do in the body (their functions), and their sources. Major minerals Mineral Function Sources Sodium Needed for proper fluid balance, nerve transmission, and muscle contraction Table salt, soy sauce; large amounts in processed foods; small amounts in milk, breads, vegetables, and unprocessed meats Chloride Needed for proper fluid balance, stomach acid Table salt, soy sauce; large amounts in processed foods; small amounts in milk, meats, breads, and vegetables Potassium Needed for proper fluid balance, nerve transmission, and muscle contraction Meats, milk, fresh fruits and vegetables, whole grains, legumes Calciu...
5 comments
Read more

THE SMOOTHIE DIET

WHAT MAKES THE SMOOTHIE DIET  DIFFERENT? This Is  NOT  just a big book of smoothie recipes. You're getting the same proven 3-Week weight loss and health improvement program I share with my private clients. The secret that makes the Smoothie Diet so effective is the Custom  3-Week Weight Loss Schedule . All the smoothies are given in a very specific sequence and frequency to maximize your results. For example the nutrient and ingredient ratios vary week to week to make sure the weight keeps coming off and stays off. I’ve used my knowledge as a Health Coach and what I’ve learned from all my clients to make sure this  program delivers rapid results . I have meticulously researched specific ingredients and nutrient properties to maximize the effectiveness of this program. All you have to do is replace certain meals with the smoothie recipes I provide and then watch as the pounds melt effortlessly off your body and your energy levels skyrocket   GET AN INSTAN...
Post a Comment
Read more

Adrenal Support Supplement

  Adrenal Support Supplement Cortisol Health LES Labs Cortisol Health , Adrenal Support Supplement for Stress Relief, Balanced Cortisol Response & Adrenal Fatigue with Phosphatidylserine & Ashwagandha, 60 Capsules. About this item SUPPORTS HEALTHY ADRENAL FUNCTION. Drug-free formula supports adrenal function and helps to control cortisol levels. PROMOTES HEALTHY CORTISOL LEVELS. Formulated to promote balanced cortisol response, a powerful hormone released during times of stress. SUPPORTS RELAXATION AND HELPS REDUCE STRESS. Ashwagandha and rhodiola extracts help promote relaxation. Included magnesium provides an added calming effect. NATURAL INGREDIENTS. Natural formula including phosphatidylserine, magnesium, ashwagandha, magnolia, and rhodiola root extract. 100% MONEY-BACK GUARANTEE. Try Cortisol Health and see how it works for you. All LES Labs supplements include a 60-day money-back guarantee - just contact LES Labs if you're not completely happy & healthy for a refu...
Post a Comment
Read more