Skip to main content

Study suggests how to treat diastolic heart failure


Study suggests how to treat diastolic heart failure

Research shows magnesium improves a form of heart failure previously without treatment

Image result for mitochondria
Research out of University Minnesota Medical School and published in the Journal of Clinical Investigation Insight uncovers what causes diastolic heart failure and how it can be treated.
In the article, "Magnesium supplementation improves diabetic mitochondrial and cardiac diastolic function," author Samuel Dudley, MD, PhD, Academic Chief of Cardiology at the University of Minnesota Medical School and his fellow researchers found that magnesium can be used to treat diastolic heart failure.
"We've found that cardiac mitochondrial oxidative stress can cause diastolic dysfunction. Since magnesium is an essential element for mitochondrial function, we decided to try the supplement as a treatment," explained Dudley. "It eliminated the poor heart relaxation that causes diastolic heart failure."
Obesity and diabetes are known risk factors for cardiovascular disease. Researchers discovered the magnesium supplement also improved the mitochondrial function and blood glucose in the subjects.
Patients with diastolic heart failure have a high morbidity, mortality, and healthcare costs. Patients with this condition have similar annual mortality to patients with systolic heart failure, and up until now there was no known specific treatments for this type of heart failure.
"This is an exciting step forward in the cardiovascular field," said Dudley, "Right now there are no specific treatments for patients with diastolic heart failure, but now we have a theory of why diastolic heart failure occurs and what we can do to get rid of it."
The next step is human trials. Dudley says this work could also open doors for answers for a related condition, atrial fibrillation.
Story Source:
Materials provided by University of Minnesota Medical School. Note: Content may be edited for style and length.
Journal Reference:
  1. Man Liu, Euy-Myoung Jeong, Hong Liu, An Xie, Eui Young So, Guangbin Shi, Go Eun Jeong, Anyu Zhou, Samuel C. Dudley. Magnesium supplementation improves diabetic mitochondrial and cardiac diastolic function. JCI Insight, 2019; 4 (1) DOI: 10.1172/jci.insight.123182
Labels:

Comments

Post a Comment

Popular posts from this blog

B-group vitamins can improve concentration among people with first episode psychosis

B-group vitamins can improve concentration among people with first episode psychosis take vitamins today B-group vitamins may be beneficial for maintaining concentration skills among people experiencing a first episode of psychosis, a study by researchers from Orygen, the National Centre of Excellence in Youth Mental Health, has found. take vitamins today The study, led by Dr Colin O'Donnell, now at Letterkenny University Hospital, and Dr Kelly Allott from Orygen, explored the impact of increasing a person's intake of vitamins B12, B6, and folic acid [vitamin B9] after studies in people with schizophrenia revealed that increased intake of these vitamins could decrease patients' levels of an amino acid called homocysteine and improve their symptoms. Dr Allott said elevated levels of homocysteine in people living with schizophrenia had been associated with more severe symptoms. "Given previous studies have shown that increasing the intake of vitamin B12, B6...
Post a Comment
Read more

Master regulator in mitochondria is critical for muscle function and repair

Master regulator in mitochondria is critical for muscle function and repair When we exercise, our muscles can become fatigued, sore and even damaged with very strenuous activities, like running a marathon. Over time our muscles are able to repair themselves through a complex set of cellular processes within each muscle fiber. New research from the MitoCare Center at Thomas Jefferson University, in collaboration with the Center for Genetic Medicine Research at Children's National Health System in Washington D.C., has identified how MICU1, a protein in the mitochondria, the "powerhouses" of all cells, is critical in the maintenance of muscle size and function, and the repair of damaged muscle fibers. The findings point to a potential role of MICU1 in neuromuscular diseases. The study was published in  Cell Reports  on October 29th. The contraction and relaxation of our muscles is dependent on the proper balance of calcium ions inside each muscle fiber. Some of this ...
Post a Comment
Read more

Mitochondria Has A Role In Cellular Copper Regulation

Mitochondria Has A Role In Cellular Copper Regulation Copper is an essential part of our lives. From copper pipes and wires - to important copper-containing proteins in the body, copper is necessary for healthy growth and neurological development. Researchers at the Montreal Neurological Institute at McGill University are studying how copper is processed in our bodies and its distinct role in early development. Their findings, published in a recent edition of the journal Cell Metabolism, identify a new role for two proteins involved with copper regulation. This study may lead to a better understanding of how to treat individuals affected by copper imbalances. "Copper is important in maintaining healthy cells. When copper is not properly regulated in the body it can lead to diseases of the liver, kidneys, brains and eyes," says Dr. Eric Shoubridge, a professor of Human Genetics at the Montreal Neurological Institute, McGill University and lead investigator. "W...
Post a Comment
Read more